Regulation of calcineurin-mediated signaling

Across TCGA patient cohorts, RNA activity of the Regulation of calcineurin-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN4, PDE1A, and RCAN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcineurin-mediated signaling activity versus SEPTIN4 in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4 →	+0.845	+0.201	<.001	<.001	3	5
LSCC	PDE1A →	+0.498	+0.295	.003	.005	3	5
GBM	RCAN2 →	+1.058	+0.179	.005	.003	3	5
GBM	SGIP1 →	+0.608	+0.189	.002	.005	3	5
LSCC	GYPC →	+0.626	+0.271	<.001	.008	3	5
BRCA	CACNA1C →	+0.650	+0.252	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106056 vs SEPTIN4 — GBM

Explore this scatter interactively →