Regulation of calcineurin-mediated signaling

Across TCGA cell cohorts, RNA activity of the Regulation of calcineurin-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOCK5, TACC1, and ANKRD46, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcineurin-mediated signaling activity versus DOCK5 in BONE (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DOCK5 →	+2.547	+0.487	.003	<.001	3	5
BONE	TACC1 →	+1.307	+0.475	.002	<.001	3	5
BONE	ANKRD46 →	-1.223	-0.435	<.001	<.001	3	4
BONE	COCH →	-3.792	-0.512	.005	.001	3	4
BLOOD_Leukemia	TOM1L2 →	+0.667	+0.337	.001	.005	3	4
URINARY_TRACT	ARAP3 →	+2.766	+0.268	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106056 vs DOCK5 — BONE

Explore this scatter interactively →