Intestinal hexose absorption

Across TCGA cell cohorts, RNA activity of the Intestinal hexose absorption pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH18, PHOX2A, and CBFA2T2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDH18 grouped by Intestinal hexose absorption-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CDH18 →	+0.392	+0.515	.003	.003	3	3
STOMACH	PHOX2A →	+0.229	+0.515	<.001	<.001	3	3
STOMACH	CBFA2T2 →	-0.402	-0.602	.003	.002	3	3
LUNG_SCLC	PLK4 →	-0.346	-0.292	.003	.004	3	3
LARGE_INTESTINE	SLC4A8 →	-0.139	-0.231	.006	.001	3	3
LARGE_INTESTINE	PMS2P5 →	-0.132	-0.259	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDH18 by Intestinal hexose absorption activity — STOMACH

Explore this box plot interactively →