Mitotic nuclear membrane organization

Across TCGA patient cohorts, RNA activity of the Mitotic nuclear membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMP14, PTER, and CD2AP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic nuclear membrane organization activity versus MMP14 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MMP14 →	+0.427	+0.025	.001	<.001	3	5
CCRCC	PTER →	-0.526	-0.041	<.001	<.001	3	5
COAD	CD2AP →	-0.207	-0.029	.008	.004	2	6
HNSC	SPINDOC_S308 →	+0.591	+0.064	<.001	<.001	3	5
HNSC	CENPF →	+0.398	+0.047	<.001	.001	3	5
CCRCC	GMPR2 →	-0.346	-0.037	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0101024 vs MMP14 — BRCA

Explore this scatter interactively →