Mitotic nuclear membrane organization

Across TCGA patient cohorts, RNA activity of the Mitotic nuclear membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAMR1, GDF10, and FAM98A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic nuclear membrane organization activity versus PAMR1 in CCRCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PAMR1 →	-0.798	-0.171	<.001	.009	3	4
UCEC	GDF10 →	-0.421	-0.154	.001	.003	3	4
GBM	FAM98A →	+0.240	+0.188	<.001	.003	3	4
BRCA	NBEA →	-0.734	-0.156	.002	.003	3	4
PDAC	AQP8 →	-2.277	-0.203	<.001	<.001	3	4
CCRCC	TNN →	-0.583	-0.229	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0101024 vs PAMR1 — CCRCC

Explore this scatter interactively →