Mitotic nuclear membrane organization

Across TCGA cell cohorts, RNA activity of the Mitotic nuclear membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTN4, CD63, and GBP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic nuclear membrane organization activity versus ACTN4 in OESOPHAGUS (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ACTN4 →	-1.240	-0.220	<.001	.001	3	6
LUNG_SCLC	CD63 →	-0.933	-0.193	<.001	<.001	3	6
STOMACH	GBP3 →	-2.871	-0.186	.002	.004	3	6
KIDNEY	RPS26 →	+1.422	+0.323	.007	.007	3	5
OESOPHAGUS	SIRT2 →	-1.495	-0.232	<.001	<.001	3	5
BONE	ALDH3B1 →	-3.199	-0.208	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0101024 vs ACTN4 — OESOPHAGUS

Explore this scatter interactively →