Neurotransmitter receptor localization to postsynaptic specialization membrane

Across TCGA patient cohorts, RNA activity of the Neurotransmitter receptor localization to postsynaptic specialization membrane pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAP3, HDAC11, and HOPX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter receptor localization to postsynaptic specialization membrane activity versus PGAP3 in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PGAP3 →	+1.742	+0.730	<.001	.001	3	4
GBM	HDAC11 →	+0.555	+0.864	<.001	<.001	3	4
BRCA	HOPX →	+0.771	+0.600	<.001	.001	3	4
CCRCC	CDR2L →	+0.406	+0.481	<.001	.001	3	4
CCRCC	RN7SL253P →	+0.463	+0.698	.002	<.001	3	4
OV	GJB1 →	+1.292	+0.704	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099645 vs PGAP3 — BRCA

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