Axo-dendritic protein transport

Across TCGA patient cohorts, RNA activity of the Axo-dendritic protein transport pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK8IP3, FAM193B, and OLFML2B, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axo-dendritic protein transport activity versus MAPK8IP3 in SCLC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	MAPK8IP3 →	+1.079	+0.185	.008	<.001	1	28
KIRC	FAM193B →	+0.987	+0.091	<.001	<.001	3	23
BLCA	OLFML2B →	-1.178	-0.051	<.001	<.001	3	23
KIRC	EME2 →	+1.051	+0.105	<.001	<.001	3	22
UVM	GTF2IP20 →	+1.104	+0.097	<.001	<.001	3	22
TGCT	CDH11 →	-1.398	-0.061	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099640 vs MAPK8IP3 — SCLC

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