Axo-dendritic protein transport

Across TCGA pan-cancer cohorts, RNA activity of the Axo-dendritic protein transport pathway differs between tumor and matched normal tissue in 8 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BLCA, show the opposite pattern, with lower activity in tumor tissue.

KICH, COAD, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	Male	IV	+0.153	<.001	11	view →
COAD	Female	II,III,IV	+0.105	<.001	11	view →
KIRP	Female	All	+0.122	<.001	9	view →
KIRC	All	All	+0.021	.002	8	view →
BRCA	Female	All	+0.039	<.001	6	view →
CHOL	Female	All	+0.226	.001	2	view →
BLCA	Male	III,IV	−0.071	.042	1	view →
ESCA	Female	All	+0.043	.004	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 8 strongest of 8 lineages.

GO:0099640–KICH

Open the KICH breakdown →