Axo-dendritic protein transport

Across TCGA patient cohorts, RNA activity of the Axo-dendritic protein transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NNMT, TLN1, and RCN3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axo-dendritic protein transport activity versus NNMT in GBM (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NNMT →	-1.187	-0.111	<.001	<.001	3	7
UCEC	TLN1 →	-0.334	-0.080	.004	.003	3	7
GBM	RCN3 →	-0.677	-0.118	.002	<.001	3	6
GBM	CRTAP →	-0.630	-0.132	<.001	<.001	3	6
OV	CS →	+0.267	+0.082	.005	<.001	3	6
OV	FHL3 →	-0.589	-0.068	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099640 vs NNMT — GBM

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