Axo-dendritic protein transport

Across TCGA patient cohorts, RNA activity of the Axo-dendritic protein transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THY1, MAP1A, and CNRIP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axo-dendritic protein transport activity versus THY1 in CCRCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	THY1 →	+0.957	+0.629	<.001	.007	3	9
HNSC	MAP1A →	+1.181	+1.169	<.001	<.001	3	9
OV	CNRIP1 →	+0.784	+0.598	<.001	.001	3	8
PDAC	ZCCHC24 →	+0.676	+1.150	<.001	<.001	3	8
LUAD	JCAD →	+0.645	+0.921	<.001	<.001	3	8
BRCA	SPARC →	+1.136	+0.933	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099640 vs THY1 — CCRCC

Explore this scatter interactively →