Axo-dendritic protein transport

Across TCGA cell cohorts, RNA activity of the Axo-dendritic protein transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATAD2B, SETD1B, and POU2F1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GATAD2B grouped by Axo-dendritic protein transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GATAD2B →	+0.801	+1.404	<.001	.002	3	5
LIVER	SETD1B →	+0.592	+1.416	.006	.004	2	5
BONE	POU2F1 →	+0.752	+1.444	.001	.001	3	4
BONE	GLG1 →	+1.785	+1.794	.008	.001	3	4
SKIN	IMMP2L →	-1.256	-0.788	<.001	<.001	3	4
BLOOD_Leukemia	BPNT1 →	+0.734	+0.998	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GATAD2B by Axo-dendritic protein transport activity — BONE

Explore this box plot interactively →