Axo-dendritic protein transport

Across TCGA cell cohorts, RNA activity of the Axo-dendritic protein transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MECP2, IRAK1, and ZNF275, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axo-dendritic protein transport activity versus MECP2 in BREAST (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MECP2 →	+0.885	+0.119	<.001	.003	3	14
PANCREAS	IRAK1 →	+1.135	+0.104	.001	<.001	3	11
LUNG_NSCLC_LUAD	ZNF275 →	+0.519	+0.089	.006	.003	3	11
BONE	MAPK8IP3 →	+1.509	+0.116	<.001	.001	3	10
BLOOD_Myeloma	XIAP →	+1.280	+0.171	<.001	.001	3	10
LUNG_SCLC	GDI1 →	+1.261	+0.158	<.001	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099640 vs MECP2 — BREAST

Explore this scatter interactively →