Axo-dendritic protein transport

Across TCGA cell cohorts, RNA activity of the Axo-dendritic protein transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB1, CBR3, and KIAA1614, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axo-dendritic protein transport activity versus HSPB1 in BLOOD_Lymphoma (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HSPB1 →	+3.115	+0.453	<.001	.002	3	7
BONE	CBR3 →	+1.919	+0.333	.003	<.001	3	5
SKIN	KIAA1614 →	+0.592	+0.166	.008	.002	3	4
LUNG_NSCLC_LUSC	DEGS1 →	+1.172	+0.381	<.001	<.001	3	4
LARGE_INTESTINE	CAMSAP2 →	+0.698	+0.331	.002	.003	3	4
LUNG_SCLC	TUBA1B →	+0.617	+0.297	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099640 vs HSPB1 — BLOOD_Lymphoma

Explore this scatter interactively →