Cardiac muscle cell membrane repolarization

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell membrane repolarization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPX, DACT3, and PRKG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell membrane repolarization activity versus SRPX in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPX →	+1.183	+0.854	<.001	<.001	3	7
CCRCC	DACT3 →	+0.844	+1.033	<.001	<.001	3	7
BRCA	PRKG1 →	+0.709	+0.983	<.001	<.001	3	7
LSCC	AOC3 →	+0.764	+0.715	<.001	<.001	3	6
CCRCC	CNN1 →	+1.988	+1.006	<.001	<.001	3	6
BRCA	MSRB3 →	+0.795	+0.638	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099622 vs SRPX — BRCA

Explore this scatter interactively →