Cardiac muscle cell membrane repolarization

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac muscle cell membrane repolarization pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 38 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Cardiac muscle cell membrane repolarization pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and ESCA, show the opposite pattern, with higher activity associated with better survival.

ACC, UVM, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.833	0.396	<.001	77	view →
UVM	DFS	Tertile	III,IV	0.321	0.844	<.001	68	view →
UCEC	DFS	Tertile	All	0.671	0.807	<.001	42	view →
ESCA	OS	Median	III,IV	0.723	0.396	<.001	36	view →
SARC	OS	Tertile	All	0.843	0.644	<.001	30	view →
LIHC	OS	Quartile	II,III,IV	0.974	0.277	.007	30	view →
DLBC	DFS	Tertile	All	0.435	1.000	.008	29	view →
THCA	DFS	Quartile	All	0.959	0.773	.001	26	view →
CHOL	OS	Median	III,IV	0.162	0.915	.004	18	view →
UCS	DFS	Quartile	II,III,IV	0.794	0.235	.002	16	view →
THYM	OS	Tertile	All	0.783	1.000	.010	14	view →
STAD	OS	Median	IV	0.509	0.183	.021	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0099622–ACC (OS)

Open the ACC breakdown →