Neurotransmitter receptor internalization

Across TCGA cell cohorts, RNA activity of the Neurotransmitter receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIZ1, PAQR5, and DPP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CIZ1 grouped by Neurotransmitter receptor internalization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CIZ1 →	-0.809	-0.283	.004	.002	3	4
SKIN	PAQR5 →	-1.024	-1.186	<.001	.002	3	4
SKIN	DPP3 →	+0.712	+0.932	.001	.008	3	4
CNS	ADAM12 →	-2.418	-0.902	<.001	<.001	3	3
LUNG_NSCLC_LUAD	JAK1 →	-0.869	-0.506	<.001	.007	3	3
BONE	BRCA2 →	+1.136	+1.694	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CIZ1 by Neurotransmitter receptor internalization activity — PANCREAS

Explore this box plot interactively →