Maintenance of synapse structure

Across TCGA patient cohorts, RNA activity of the Maintenance of synapse structure pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPIRE1, FBXL22, and SHANK2-AS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of synapse structure activity versus SPIRE1 in LUAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPIRE1 →	+0.427	+0.721	<.001	.002	3	4
UCEC	FBXL22 →	+0.435	+0.557	.002	.006	3	4
HNSC	SHANK2-AS2 →	+0.949	+0.636	<.001	<.001	3	4
GBM	MEG3 →	+1.083	+0.941	.003	.002	3	4
OV	UPF3B →	-0.497	-0.733	.005	.001	3	3
HNSC	KDM7A-DT →	-0.674	-0.940	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099558 vs SPIRE1 — LUAD

Explore this scatter interactively →