Maintenance of synapse structure

Across TCGA cell cohorts, RNA activity of the Maintenance of synapse structure pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SDF4, WDR12, and MRTO4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of synapse structure activity versus SDF4 in BONE (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SDF4 →	+1.542	+1.716	<.001	<.001	3	9
BONE	WDR12 →	-0.427	-0.829	.006	.009	3	6
LUNG_SCLC	MRTO4 →	-0.515	-0.971	.009	<.001	3	6
LUNG_SCLC	PUM3 →	-0.718	-1.171	<.001	<.001	3	5
BONE	CAD →	-1.192	-1.153	<.001	<.001	3	5
LUNG_SCLC	ESF1 →	-0.688	-1.063	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099558 vs SDF4 — BONE

Explore this scatter interactively →