"Trans-synaptic signaling, modulating synaptic transmission"

Across TCGA cell cohorts, RNA activity of the "Trans-synaptic signaling, modulating synaptic transmission" pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf116, SPAG16, and TAF6L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf116 grouped by "Trans-synaptic signaling, modulating synaptic transmission"-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C1orf116 →	+1.916	+1.201	.007	.001	3	4
STOMACH	SPAG16 →	+2.127	+1.032	.002	<.001	3	4
BLOOD_Leukemia	TAF6L →	+0.560	+0.906	.001	.003	3	4
STOMACH	C10orf95 →	+0.986	+1.148	.001	.002	3	4
LUNG_NSCLC_LUAD	CEP95 →	+0.407	+0.890	.005	.001	3	4
KIDNEY	CCDC66 →	+0.860	+1.076	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf116 by "Trans-synaptic signaling, modulating synaptic transmission" activity — OVARY

Explore this box plot interactively →