"Trans-synaptic signaling, modulating synaptic transmission"

Across TCGA cell cohorts, RNA activity of the "Trans-synaptic signaling, modulating synaptic transmission" pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FYCO1, PLCH2, and COASY, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FYCO1 grouped by "Trans-synaptic signaling, modulating synaptic transmission"-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FYCO1 →	-0.151	-0.155	.002	.005	3	4
LUNG_NSCLC_LUSC	PLCH2 →	-0.441	-0.162	.001	.002	3	3
BONE	COASY →	-0.292	-0.089	.006	.006	3	3
LUNG_NSCLC_LUAD	KCNB1 →	-0.185	-0.830	<.001	<.001	3	3
BONE	ITGB7 →	+0.252	+0.072	.007	.005	2	4
OVARY	FBXL4 →	+0.280	+1.528	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FYCO1 by "Trans-synaptic signaling, modulating synaptic transmission" activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →