Synaptic vesicle endosomal processing

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle endosomal processing pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN12, FUT1, and MRPL19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN12 grouped by Synaptic vesicle endosomal processing-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PTPN12 →	-0.879	-1.162	<.001	<.001	3	5
BREAST	FUT1 →	+0.784	+0.709	.006	.009	3	4
BLOOD_Leukemia	MRPL19 →	+1.084	+1.316	<.001	<.001	3	4
BLOOD_Leukemia	TGS1 →	+0.712	+1.109	.006	.003	3	4
BLOOD_Leukemia	SLC5A6 →	+1.154	+1.646	<.001	<.001	3	4
BLOOD_Leukemia	VASH2 →	+2.183	+1.186	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN12 by Synaptic vesicle endosomal processing activity — SKIN

Explore this box plot interactively →