Postsynapse to nucleus signaling pathway

Across TCGA patient cohorts, RNA activity of the Postsynapse to nucleus signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GASK1B, HNRNPA1P7, and PITRM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse to nucleus signaling pathway activity versus GASK1B in UCEC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GASK1B →	-1.139	-0.614	<.001	.003	3	4
PDAC	HNRNPA1P7 →	+0.619	+0.630	<.001	<.001	3	3
GBM	PITRM1 →	-0.323	-0.545	<.001	.008	3	3
LUAD	SNX18 →	-0.454	-0.555	<.001	<.001	3	3
UCEC	RNFT1 →	-0.657	-0.852	.007	<.001	3	3
LSCC	SFRP4 →	-0.881	-0.554	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099527 vs GASK1B — UCEC

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