Postsynapse to nucleus signaling pathway

Across TCGA cell cohorts, RNA activity of the Postsynapse to nucleus signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLA2, FIP1L1, and PRR13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse to nucleus signaling pathway activity versus POLA2 in LIVER (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	POLA2 →	+1.227	+0.480	<.001	.004	3	5
CNS	FIP1L1 →	+0.558	+1.152	.004	.003	3	4
CNS	PRR13 →	+0.380	+0.615	.008	.008	3	4
LIVER	ZDHHC5 →	+0.610	+0.403	.006	.008	3	4
LIVER	DDB1 →	+0.949	+0.390	<.001	<.001	3	4
LIVER	TCOF1 →	+1.150	+0.442	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099527 vs POLA2 — LIVER

Explore this scatter interactively →