Vesicle cytoskeletal trafficking

Across TCGA patient cohorts, RNA activity of the Vesicle cytoskeletal trafficking pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2, MICALL1, and RPS8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle cytoskeletal trafficking activity versus MAP2 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP2 →	+0.669	+0.033	.001	<.001	3	6
PDAC	MICALL1 →	-0.271	-0.031	<.001	.001	3	6
BRCA	RPS8 →	-0.331	-0.034	.001	<.001	3	5
GBM	ARFGEF3 →	+0.476	+0.038	<.001	<.001	3	5
LSCC	PICK1 →	+0.354	+0.035	.001	<.001	3	5
CCRCC	IMPDH2 →	-0.203	-0.029	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099518 vs MAP2 — LSCC

Explore this scatter interactively →