Vesicle cytoskeletal trafficking

Across TCGA cell cohorts, RNA activity of the Vesicle cytoskeletal trafficking pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2F1, GRPR, and RPH3AL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2F1 grouped by Vesicle cytoskeletal trafficking-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GTF2F1 →	-0.748	-1.127	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	GRPR →	-0.180	-1.297	.006	.002	2	5
UPPER_AERODIGESTIVE_TRACT	RPH3AL →	-1.851	-1.446	.002	.002	3	4
LUNG_NSCLC_LUAD	RPRD2 →	+0.716	+1.028	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SCAMP4 →	-1.288	-1.682	<.001	<.001	3	4
LIVER	MED11 →	-0.921	-0.279	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2F1 by Vesicle cytoskeletal trafficking activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →