Vesicle cytoskeletal trafficking

Across TCGA cell cohorts, RNA activity of the Vesicle cytoskeletal trafficking pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF9, SYNJ2BP, and PLAG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle cytoskeletal trafficking activity versus KIF9 in URINARY_TRACT (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KIF9 →	-0.986	-0.755	<.001	.004	3	5
BLOOD_Leukemia	SYNJ2BP →	-1.632	-0.961	<.001	<.001	3	4
PANCREAS	PLAG1 →	+1.474	+0.308	<.001	.002	3	4
LARGE_INTESTINE	EIF3H →	-0.497	-0.376	.001	.004	3	4
LUNG_SCLC	ATP8A1 →	-2.474	-0.727	<.001	.006	3	4
SKIN	LYAR →	-0.578	-0.130	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099518 vs KIF9 — URINARY_TRACT

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