Regulation of presynaptic cytosolic calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Regulation of presynaptic cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALB2, CNR1, and ADORA1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of presynaptic cytosolic calcium ion concentration activity versus CALB2 in ESCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	CALB2 →	+2.451	+0.251	<.001	.001	3	18
DLBC	CNR1 →	+2.268	+0.079	<.001	<.001	3	18
PCPG	ADORA1 →	+1.347	+0.033	<.001	.001	2	18
STAD	FAM107A →	+1.192	+0.176	<.001	<.001	3	15
SCLC	DUSP26 →	+2.682	+1.020	<.001	.001	3	14
LGG	SV2B →	+2.522	+0.102	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099509 vs CALB2 — ESCA

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