Regulation of presynaptic cytosolic calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Regulation of presynaptic cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS4, FAM189A1, and DIRAS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of presynaptic cytosolic calcium ion concentration activity versus RGS4 in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RGS4 →	+1.108	+0.919	.001	<.001	3	3
BRCA	FAM189A1 →	+0.509	+0.959	.001	<.001	3	3
LUAD	DIRAS1 →	+0.852	+0.423	<.001	.001	3	3
OV	LOX →	+1.280	+0.935	.005	.001	3	3
OV	ALDH1L2 →	+0.858	+1.061	.005	<.001	3	3
OV	STXBP5-AS1 →	+0.187	+1.093	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099509 vs RGS4 — GBM

Explore this scatter interactively →