Regulation of presynaptic cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Regulation of presynaptic cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP1B, SEPHS2, and ILF3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of presynaptic cytosolic calcium ion concentration activity versus RRP1B in STOMACH (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RRP1B →	+0.898	+1.589	.003	<.001	3	3
CNS	SEPHS2 →	-0.810	-1.467	.001	.003	3	3
LUNG_SCLC	ILF3 →	+0.577	+1.060	<.001	.001	3	3
LUNG_SCLC	HSD17B14 →	-1.785	-1.192	.009	.001	3	2
BREAST	KAT2A →	+1.214	+1.450	.002	<.001	3	2
BREAST	KCNC4 →	+2.104	+1.441	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099509 vs RRP1B — STOMACH

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