Vesicle fusion to plasma membrane

Across TCGA patient cohorts, RNA activity of the Vesicle fusion to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-1310P, SCN1B, and ALDH1A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle fusion to plasma membrane activity versus RNU6-1310P in PDAC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RNU6-1310P →	-0.498	-0.452	.003	.003	3	5
GBM	SCN1B →	+0.659	+0.525	<.001	<.001	3	5
GBM	ALDH1A1 →	+0.849	+0.446	.007	.007	3	4
CCRCC	TPM4 →	-0.400	-0.363	.002	.004	3	4
PDAC	PRKDC →	-0.212	-0.462	.005	.001	3	4
PDAC	LINC02544 →	-0.912	-0.448	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099500 vs RNU6-1310P — PDAC

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