Vesicle fusion to plasma membrane

Across TCGA cell cohorts, RNA activity of the Vesicle fusion to plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1A1, AOAH, and STAU1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSNK1A1 grouped by Vesicle fusion to plasma membrane-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSNK1A1 →	-0.305	-0.125	.003	.002	3	4
OESOPHAGUS	AOAH →	-0.210	-0.126	.005	.006	3	4
LUNG_NSCLC_LUSC	STAU1 →	+0.215	+0.168	.001	<.001	3	4
BLOOD_Leukemia	FUT1 →	-0.338	-0.151	.005	<.001	3	4
LIVER	PREX2 →	-0.123	-0.084	.006	.006	3	4
SKIN	HDAC6 →	-0.180	-0.158	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSNK1A1 by Vesicle fusion to plasma membrane activity — LARGE_INTESTINE

Explore this box plot interactively →