Presynapse organization

Across TCGA patient cohorts, RNA activity of the Presynapse organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCCHC24, SRPX2, and GABRB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynapse organization activity versus ZCCHC24 in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZCCHC24 →	+0.699	+1.002	.001	.002	3	5
LSCC	SRPX2 →	+0.665	+0.174	<.001	<.001	3	5
GBM	GABRB2 →	+0.923	+1.460	<.001	<.001	3	4
OV	TNIK →	+0.767	+0.173	.001	<.001	3	4
OV	UBTD2 →	+0.508	+0.165	<.001	<.001	3	4
OV	C1QTNF3 →	+1.614	+0.212	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099172 vs ZCCHC24 — GBM

Explore this scatter interactively →