Regulation of modification of postsynaptic structure

Across TCGA patient cohorts, RNA activity of the Regulation of modification of postsynaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S1PR2, PHF5GP, and MIIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of modification of postsynaptic structure activity versus S1PR2 in HNSC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	S1PR2 →	-0.393	-0.466	<.001	<.001	3	4
LUAD	PHF5GP →	-0.735	-0.212	.002	.006	3	3
BRCA	MIIP →	-0.800	-0.560	<.001	.004	3	3
BRCA	P3H1 →	-0.718	-0.463	<.001	.002	3	3
BRCA	RER1 →	-0.240	-0.419	.003	<.001	3	3
BRCA	PSMB4 →	-0.626	-0.601	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099159 vs S1PR2 — HNSC

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