Regulation of postsynaptic density assembly

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic density assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCER1G, SPI1, and TNFAIP8L2, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic density assembly activity versus FCER1G in BLCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FCER1G →	+1.213	+0.039	<.001	<.001	3	20
ESCA	SPI1 →	+1.069	+0.076	<.001	<.001	3	20
DLBC	TNFAIP8L2 →	+0.983	+0.088	.002	.004	1	21
OV	LSP1 →	+0.881	+0.064	<.001	<.001	3	19
BLCA	LST1 →	+0.962	+0.041	<.001	<.001	3	19
BLCA	HCK →	+1.081	+0.043	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099151 vs FCER1G — BLCA

Explore this scatter interactively →