Regulation of postsynaptic density assembly

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic density assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HTRA3, MMP2, and MYH9_S841, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic density assembly activity versus HTRA3 in PDAC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HTRA3 →	+0.583	+0.054	<.001	.001	3	5
LSCC	MMP2 →	+0.578	+0.076	.002	<.001	3	5
LSCC	MYH9_S841 →	+0.836	+0.084	<.001	<.001	3	5
LUAD	NAV1 →	+0.404	+0.077	<.001	<.001	3	5
LUAD	ARPC5 →	+0.216	+0.086	<.001	<.001	3	5
LUAD	UPP1 →	+0.552	+0.052	.002	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099151 vs HTRA3 — PDAC

Explore this scatter interactively →