Regulation of postsynaptic neurotransmitter receptor internalization

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic neurotransmitter receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUNX3, PCBD1, and RNU6-237P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic neurotransmitter receptor internalization activity versus RUNX3 in BRCA (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RUNX3 →	-0.607	-0.623	.006	.005	3	4
HNSC	PCBD1 →	+0.768	+0.662	.005	.002	3	3
BRCA	RNU6-237P →	-0.389	-0.493	.007	.006	3	3
COAD	LMNB1 →	-0.524	-0.788	<.001	.002	3	3
COAD	RPL39P18 →	-0.504	-0.822	.006	.002	3	3
COAD	DLEU2 →	-0.177	-0.699	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099149 vs RUNX3 — BRCA

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