tRNA 5'-end processing

Across TCGA patient cohorts, RNA activity of the tRNA 5'-end processing pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TTK_S436, RPP25, and SMC4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA 5'-end processing activity versus TTK_S436 in LUAD (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TTK_S436 →	+0.955	+0.068	<.001	<.001	3	8
BRCA	RPP25 →	+0.420	+0.052	<.001	<.001	3	7
LUAD	SMC4 →	+0.540	+0.072	<.001	<.001	3	7
LSCC	DNMT1_S714 →	+0.680	+0.065	<.001	<.001	3	7
LUAD	RPP25_S162 →	+0.798	+0.056	<.001	.001	3	7
LUAD	ANXA2_S164 →	-0.606	-0.048	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099116 vs TTK_S436 — LUAD

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