Microtubule-based transport

Across TCGA patient cohorts, RNA activity of the Microtubule-based transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTCB, CHKB, and ARFGAP1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule-based transport activity versus RTCB in COAD (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RTCB →	+0.724	+1.216	.007	.005	3	1
COAD	CHKB →	-0.299	-1.137	.001	.006	3	1
COAD	ARFGAP1 →	-1.162	-1.468	.004	.002	3	1
COAD	TRPA1 →	+1.807	+1.381	<.001	.003	3	1
COAD	TYRP1 →	+0.691	+1.302	.001	<.001	3	1
COAD	DHRS7B →	+0.710	+1.560	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099111 vs RTCB — COAD

Explore this scatter interactively →