Microtubule-based transport

Across TCGA cell cohorts, RNA activity of the Microtubule-based transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXADR, MARVELD1, and MOSPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CXADR grouped by Microtubule-based transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CXADR →	-2.530	-0.187	.002	<.001	3	6
URINARY_TRACT	MARVELD1 →	+1.425	+0.176	<.001	.001	3	5
STOMACH	MOSPD1 →	+1.350	+0.208	<.001	.001	3	5
BONE	POLG →	-0.603	-0.189	.002	<.001	3	4
LARGE_INTESTINE	RIN2 →	+1.054	+0.096	.005	.002	3	4
LARGE_INTESTINE	FBLIM1 →	+1.655	+0.109	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CXADR by Microtubule-based transport activity — BONE

Explore this box plot interactively →