Postsynapse assembly

Across TCGA patient cohorts, RNA activity of the Postsynapse assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DBN1, SERPINF1, and TIMP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse assembly activity versus DBN1 in LSCC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DBN1 →	+0.437	+0.040	<.001	.006	3	7
CCRCC	SERPINF1 →	+0.523	+0.040	.002	<.001	3	6
HNSC	TIMP2 →	+0.418	+0.034	<.001	.004	3	6
PDAC	AEBP1 →	+0.469	+0.032	<.001	<.001	3	6
CCRCC	COL5A1 →	+0.690	+0.038	.001	<.001	2	7
CCRCC	COL5A2 →	+0.550	+0.037	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099068 vs DBN1 — LSCC

Explore this scatter interactively →