Postsynapse assembly

Across TCGA pan-cancer cohorts, RNA activity of the Postsynapse assembly pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 39 member genes.

The strongest signal is observed in thyroid carcinoma (THCA), where higher Postsynapse assembly pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THCA and UCS, show the opposite pattern, with higher activity associated with better survival.

THCA, ACC, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.990	0.890	.004	55	view →
ACC	DFS	Tertile	II,III,IV	0.364	0.782	<.001	50	view →
STAD	DFS	Quartile	All	0.182	0.465	.003	49	view →
UCS	DFS	Median	II,III,IV	0.500	0.149	.001	32	view →
MESO	OS	Tertile	All	0.276	0.480	.005	27	view →
SARC	OS	Tertile	All	0.341	0.768	<.001	27	view →
OV	DFS	Quartile	II,III,IV	0.207	0.118	.023	24	view →
LIHC	OS	Median	III,IV	0.757	0.552	.017	19	view →
ESCA	DFS	Median	IV	0.704	0.249	.013	18	view →
HNSC	DFS	Quartile	IV	0.575	0.276	.009	18	view →
SKCM	OS	Median	All	0.810	0.924	.002	18	view →
LAML	DFS	Quartile	All	0.227	0.648	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0099068–THCA (OS)

Open the THCA breakdown →