Postsynapse assembly

Across TCGA patient cohorts, RNA activity of the Postsynapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK8IP1, RASL12, and PRPH2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse assembly activity versus MAPK8IP1 in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAPK8IP1 →	+0.700	+0.284	.007	<.001	3	7
CCRCC	RASL12 →	+0.667	+1.037	<.001	<.001	3	5
BRCA	PRPH2 →	+0.414	+0.353	<.001	.008	3	5
CCRCC	CNRIP1 →	+0.744	+1.164	<.001	<.001	3	5
COAD	RHOB →	+0.873	+0.517	<.001	.002	3	5
CCRCC	VIP →	+0.598	+0.943	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099068 vs MAPK8IP1 — GBM

Explore this scatter interactively →