Postsynapse assembly

Across TCGA cell cohorts, RNA activity of the Postsynapse assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRKL, CRK, and SLC4A4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRKL grouped by Postsynapse assembly-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CRKL →	-0.293	-1.273	.003	.008	3	8
STOMACH	CRK →	-0.282	-1.080	<.001	.002	3	6
BLOOD_Leukemia	SLC4A4 →	-0.290	-0.642	.002	.006	3	5
LIVER	PAXIP1 →	+0.238	+1.543	.002	<.001	2	6
CNS	DENND1B →	-0.185	-0.957	.003	<.001	3	5
CNS	SCGN →	-0.226	-1.002	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRKL by Postsynapse assembly activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →