Postsynapse assembly

Across TCGA cell cohorts, RNA activity of the Postsynapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJB5, ASMTL, and PTAFR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse assembly activity versus GJB5 in PANCREAS (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GJB5 →	-3.958	-1.570	.001	<.001	3	5
LARGE_INTESTINE	ASMTL →	+0.741	+0.824	<.001	.002	3	5
URINARY_TRACT	PTAFR →	-3.860	-1.820	<.001	<.001	2	6
LARGE_INTESTINE	LAMA3 →	-1.376	-0.753	.008	.006	3	5
PANCREAS	KLK10 →	-4.251	-1.070	<.001	.001	3	5
LUNG_NSCLC_LUSC	SCLY →	+1.025	+1.688	.009	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099068 vs GJB5 — PANCREAS

Explore this scatter interactively →