Sphingolipid translocation

Across TCGA patient cohorts, RNA activity of the Sphingolipid translocation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASCC2, ACTR10, and RPS6KA4_S737, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid translocation activity versus ASCC2 in LSCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASCC2 →	-0.135	-0.049	<.001	.001	3	6
HNSC	ACTR10 →	-0.179	-0.111	<.001	<.001	3	5
LSCC	RPS6KA4_S737 →	-0.793	-0.100	.001	<.001	3	5
LSCC	ISCA1 →	+0.517	+0.085	<.001	<.001	3	5
BRCA	RPL5 →	-0.225	-0.047	<.001	.005	3	4
LSCC	ME1 →	+0.660	+0.078	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099039 vs ASCC2 — LSCC

Explore this scatter interactively →