Sphingolipid translocation

Across TCGA patient cohorts, RNA activity of the Sphingolipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIP4, PRPF4, and ABHD6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid translocation activity versus CLIP4 in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CLIP4 →	+0.241	+0.363	.006	.005	3	3
GBM	PRPF4 →	-0.357	-0.523	<.001	.005	3	3
GBM	ABHD6 →	+0.516	+0.515	<.001	<.001	3	3
GBM	SLC2A7 →	-0.073	-0.397	.002	.005	3	3
GBM	TNS1-AS1 →	-0.707	-0.496	<.001	.008	3	3
LSCC	PCGF3 →	-0.452	-0.649	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099039 vs CLIP4 — GBM

Explore this scatter interactively →