Sphingolipid translocation

Across TCGA cell cohorts, RNA activity of the Sphingolipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSE1L, TTI2, and DIS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSE1L grouped by Sphingolipid translocation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CSE1L →	+0.571	+0.922	.007	.003	3	5
LUNG_SCLC	TTI2 →	+0.634	+1.102	.002	<.001	3	4
LARGE_INTESTINE	DIS3 →	+0.708	+1.211	.002	.001	3	4
LUNG_NSCLC_LUSC	ZCCHC3 →	+0.609	+1.531	.005	<.001	2	5
LUNG_NSCLC_LUAD	HDAC9 →	-1.746	-1.006	<.001	<.001	3	4
KIDNEY	RFC3 →	+0.667	+1.080	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSE1L by Sphingolipid translocation activity — BLOOD_Leukemia

Explore this box plot interactively →