Anterograde dendritic transport of neurotransmitter receptor complex

Across TCGA patient cohorts, RNA activity of the Anterograde dendritic transport of neurotransmitter receptor complex pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPARGC1B, EIF4E3, and LINC02019, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterograde dendritic transport of neurotransmitter receptor complex activity versus PPARGC1B in OV (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PPARGC1B →	-0.744	-0.202	.006	.001	3	3
LUAD	EIF4E3 →	-0.345	-0.111	.007	.009	3	3
CCRCC	LINC02019 →	-0.231	-0.352	.001	.001	3	3
HNSC	WDTC1 →	-0.273	-0.089	.009	.009	3	3
PDAC	KDF1 →	-0.304	-0.095	.001	.001	3	3
PDAC	DNAH8-AS1 →	-0.247	-0.164	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098971 vs PPARGC1B — OV

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