Anterograde dendritic transport of neurotransmitter receptor complex

Across TCGA cell cohorts, RNA activity of the Anterograde dendritic transport of neurotransmitter receptor complex pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A15, HDAC6, and CLEC4E, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC6A15 grouped by Anterograde dendritic transport of neurotransmitter receptor complex-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC6A15 →	-0.131	-0.137	.001	.004	3	5
CNS	HDAC6 →	-0.142	-0.103	<.001	<.001	3	4
PANCREAS	CLEC4E →	-0.204	-0.137	<.001	.009	3	4
BLOOD_Myeloma	DIO2 →	+0.238	+0.109	.007	.002	3	4
SKIN	SLC39A7 →	-0.309	-0.135	.001	.003	3	4
LUNG_SCLC	MPST →	+0.130	+0.170	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC6A15 by Anterograde dendritic transport of neurotransmitter receptor complex activity — OESOPHAGUS

Explore this box plot interactively →